Alessio L, Apostoli P, Forni A, Toffoletto F
Institute of Occupational Health, University of Brescia, Italy.
Scand J Work Environ Health. 1993;19 Suppl 1:27-33.
Studies carried out over the last 12 years in northern Italy on a case list of 105 cadmium (Cd) workers showed that blood levels (B-Cd) were influenced not only by current exposure but also by body burden, while urinary levels (U-Cd) were influenced predominantly by body burden. Moreover, no advantages were gained by adjusting U-Cd for creatinine or specific gravity. The urinary beta 2-microglobulin levels were within the reference values when B-Cd and U-Cd were below the current threshold values. However, some indicators of early renal effect appeared to be altered. An increase in chromosome-type aberrations in lymphocytes occurred in workers with a heavy cadmium burden. Studies carried out on more than 600 subjects from the general population showed higher B-Cd levels in smokers than in nonsmokers. B-Cd levels were higher in men and in higher age groups. Identifying reference values for B-Cd through meta-analysis studies seems useful.
在意大利北部，过去12年对105名镉（Cd）作业工人的病例清单进行的研究表明，血液中镉水平（B-Cd）不仅受当前接触量影响，还受体内负荷影响，而尿中镉水平（U-Cd）主要受体内负荷影响。此外，对U-Cd进行肌酐或比重校正并无益处。当B-Cd和U-Cd低于当前阈值时，尿β2-微球蛋白水平在参考值范围内。然而，一些早期肾脏效应指标似乎发生了改变。镉负荷重的工人淋巴细胞中染色体型畸变增加。对600多名普通人群进行的研究表明，吸烟者的B-Cd水平高于非吸烟者。男性和年龄较大组的B-Cd水平较高。通过荟萃分析研究确定B-Cd的参考值似乎是有用的。
