通过压力破碎以及在蔗糖 - 氯化钠梯度中进行区带离心，从小鼠脑中对瘙痒病病原体进行部分纯化。 - Suppr

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超能文献

Partial purification of the scrapie agent from mouse brain by pressure disruption and zonal centrifugation in sucrose-sodium chloride gradients.

作者信息

Siakotos A N, Gajdusek D C, Gibbs C J, Traub R D, Bucana C

出版信息

Virology. 1976 Mar;70(1):230-7. doi: 10.1016/0042-6822(76)90261-0.

DOI:10.1016/0042-6822(76)90261-0

PMID:816078

Abstract

摘要

相似文献

Partial purification of the scrapie agent from mouse brain by pressure disruption and zonal centrifugation in sucrose-sodium chloride gradients.通过压力破碎以及在蔗糖 - 氯化钠梯度中进行区带离心，从小鼠脑中对瘙痒病病原体进行部分纯化。

Virology. 1976 Mar;70(1):230-7. doi: 10.1016/0042-6822(76)90261-0.

An experimental examination of the scrapie agent in cell membrane mixtures. II. The association of scrapie activity with membrane fractions.

J Comp Pathol. 1971 Apr;81(2):255-65. doi: 10.1016/0021-9975(71)90100-9.

Purification of the scrapie agent by density gradient centrifugation.

J Gen Virol. 1984 Feb;65 ( Pt 2):415-21. doi: 10.1099/0022-1317-65-2-415.

Effects of different methods of purification on aggregation of scrapie infectivity.

J Gen Virol. 1987 Jan;68 ( Pt 1):225-31. doi: 10.1099/0022-1317-68-1-225.

An experimental examination of the scrapie agent in cell membrane mixtures. I. Stability and physicochemical properties of the scrapie agent.

J Comp Pathol. 1971 Jan;81(1):23-32. doi: 10.1016/0021-9975(71)90051-x.

Lysosomal enzymes in normal and scrapie mouse brain.

J Neurochem. 1965 Jun;12(6):461-8. doi: 10.1111/j.1471-4159.1965.tb06773.x.

Equilibrium density gradient centrifugation of the scrapie agent in Nycodenz.在 Nycodenz 中对瘙痒病病原体进行平衡密度梯度离心。

J Gen Virol. 1984 Nov;65 ( Pt 11):1963-8. doi: 10.1099/0022-1317-65-11-1963.

Isolation and characterization of lysosome-rich fractions from cultured cells.从培养细胞中分离和鉴定富含溶酶体的组分。

Exp Cell Res. 1968 Feb;49(2):266-76. doi: 10.1016/0014-4827(68)90177-8.

An experimental examination of the scrapie agent in cell membrane mixtures. 3. Studies of the operational size.细胞膜混合物中瘙痒病病原体的实验检测。3. 操作尺寸研究。

J Comp Pathol. 1971 Jul;81(3):383-91. doi: 10.1016/0021-9975(71)90026-0.

The heterogeneity of lysosomes.溶酶体的异质性。

Front Biol. 1975;43(4):305-48.

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Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.朊病毒杆状结构的破坏会产生具有高α-螺旋含量且缺乏瘙痒病感染力的10纳米球形颗粒。

J Virol. 1996 Mar;70(3):1714-22. doi: 10.1128/JVI.70.3.1714-1722.1996.

Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes.小鼠的克雅氏病：持续性病毒血症及病毒在低密度淋巴细胞中的优先复制

Infect Immun. 1983 Jul;41(1):154-61. doi: 10.1128/iai.41.1.154-161.1983.

Immunoaffinity purification and neutralization of scrapie prion infectivity.免疫亲和纯化与羊瘙痒病朊病毒感染性的中和

Proc Natl Acad Sci U S A. 1988 Sep;85(18):6617-21. doi: 10.1073/pnas.85.18.6617.

Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils.针对羊瘙痒病相关纤维蛋白和朊病毒蛋白的抗血清可标记羊瘙痒病相关纤维。

J Virol. 1987 Jan;61(1):42-9. doi: 10.1128/JVI.61.1.42-49.1987.

Physical properties of the Creutzfeldt-Jakob disease agent.克雅氏病病原体的物理特性。

J Virol. 1989 Mar;63(3):1212-22. doi: 10.1128/JVI.63.3.1212-1222.1989.

Prion liposomes.朊病毒脂质体

Biochem J. 1990 Feb 15;266(1):1-14. doi: 10.1042/bj2660001.

Membrane-free scrapie activity.无膜瘙痒病活性

J Virol. 1978 Mar;25(3):933-5. doi: 10.1128/JVI.25.3.933-935.1978.

Sedimentation properties of the scrapie agent.羊瘙痒病病原体的沉降特性。

Proc Natl Acad Sci U S A. 1977 Oct;74(10):4656-60. doi: 10.1073/pnas.74.10.4656.

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