Fukuda K, Kato S, Mori K, Nishi M, Takeshima H, Iwabe N, Miyata T, Houtani T, Sugimoto T
Department of Anesthesia, Kyoto University Hospital, Japan.
FEBS Lett. 1994 Apr 18;343(1):42-6. doi: 10.1016/0014-5793(94)80603-9.
We have cloned a cDNA for a novel member of the opioid receptor family, designated as ROR-C, from the rat cerebrum cDNA library using the probe derived from the delta-opioid receptor subtype cDNA. The deduced amino acid sequence of ROR-C shows high homology with those of ROR-A (rat delta-opioid receptor subtype), ROR-B (rat mu-subtype) and ROR-D (rat kappa-subtype). RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system.
我们使用源自δ-阿片受体亚型cDNA的探针，从大鼠大脑cDNA文库中克隆了阿片受体家族一个新成员的cDNA，命名为ROR-C。ROR-C推导的氨基酸序列与ROR-A（大鼠δ-阿片受体亚型）、ROR-B（大鼠μ-亚型）和ROR-D（大鼠κ-亚型）的氨基酸序列具有高度同源性。RNA印迹杂交和原位杂交分析显示，ROR-C mRNA在大鼠中枢神经系统的离散区域表达。
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