Kurlan R, Whitmore D, Irvine C, McDermott M P, Como P G
Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642-8673.
Neurology. 1994 Apr;44(4):699-702. doi: 10.1212/wnl.44.4.699.
To determine whether children requiring special education represent a high-risk group for identifying Tourette's syndrome (TS), we performed direct examinations for the presence of tics in 35 special education and 35 regular classroom students from a single school district. Of the special education students, nine (26%) had definite or probable tics as compared with only two (6%) of the regular classroom students. About one-third of the students with tics currently meet diagnostic criteria for TS and probably more will do so in the future. About one-half of the subjects with tics have evidence of obsessive-compulsive behavior (OCB) or an attention-deficit hyperactivity disorder (ADHD). For three randomly selected students with definite tics, direct examinations of first-degree relatives revealed the presence of tics in all families. Subjects to the limitations of this pilot study, we conclude that TS and related tic disorders are commonly associated with the need for special education in this single school district. TS might also be an important contributor to school problems in the childhood population at large and may be a highly prevalent condition. In addition, we conclude that childhood tics are associated with OCB and ADHD, are genetically determined, and are part of the TS clinical spectrum.
为了确定需要特殊教育的儿童是否是识别抽动秽语综合征(TS)的高危人群,我们对来自单一学区的35名接受特殊教育的学生和35名普通课堂学生进行了抽动检查。在接受特殊教育的学生中,9名(26%)有明确或可能的抽动,而普通课堂学生中只有2名(6%)有抽动。目前,约三分之一有抽动的学生符合TS的诊断标准,未来可能会有更多学生符合。约一半有抽动的受试者有强迫行为(OCB)或注意力缺陷多动障碍(ADHD)的证据。对三名随机选择的有明确抽动的学生的一级亲属进行直接检查发现,所有家庭中都有抽动存在。鉴于这项初步研究的局限性,我们得出结论,在这个单一学区,TS及相关抽动障碍通常与需要特殊教育有关。TS也可能是导致广大儿童群体出现学校问题的一个重要因素,且可能是一种高度普遍的病症。此外,我们得出结论,儿童抽动与OCB和ADHD有关,由基因决定,并且是TS临床谱系的一部分。