Mills A M, O'Reilly C P, Collins W P
Department of Obstetrics and Gynaecology, University College Hospital, London, U.K.
Int J Fertil Menopausal Stud. 1994 Jan-Feb;39(1):32-8.
Indices of ovarian function and potential fertility have been studied in fully lactating women from the sixth week post-partum to the start of the second menstrual period.
Thirty-four women entered the study and 17 (50%) continued until the first menses. Of these, 16 continued until the second menses. The median time from delivery to day 1 of the first menses was 202 days (range, 85 to 668 days).
The concentrations of estrone glucuronide (EG) and pregnanediol glucuronide in daily samples of early morning urine were measured by time-resolved fluoroimmunoassay and LH by an immunoradiometric assay. Algorithms were used retrospectively to determine the rise and peak days of all three metabolites.
Three cycles were studied relative to day 1 of first menses: (1) premenstrual (days -60 to -31), (2) menstrual (days -30 to -1), and (3) postmenstrual (days 1 to 56). Follicular development occurred in 53%, 100% and 100% of the dated cycles respectively. A peak of LH occurred in 6%, 75% and 80% of cycles, respectively. A period of potential fertility occurred in 11/17 (65%) and 13/16 (81%) of cycles (2) and (3), respectively. The proportion of potentially fertile cycles was higher after the first menses, and after 6 months had elapsed postpartum.
A test based on the measurement of EG and used prospectively predicted 13/15 (85%) of the periods of potential fertility during the postmenstrual cycle.
对产后六周至第二次月经来潮起始阶段的完全哺乳期女性的卵巢功能指标及潜在生育能力进行了研究。
34名女性参与了该研究，其中17名（50%）持续至首次月经来潮。在这些女性中，16名持续至第二次月经来潮。从分娩至首次月经第1天的中位时间为202天（范围85至668天）。
采用时间分辨荧光免疫分析法测定晨尿每日样本中雌酮葡萄糖醛酸苷（EG）和孕二醇葡萄糖醛酸苷的浓度，采用免疫放射分析法测定促黄体生成素（LH）。回顾性地使用算法来确定所有三种代谢物的上升和峰值日期。
相对于首次月经第1天研究了三个周期：（1）经前期（-60至-31天），（2）月经期（-30至-1天），以及（3）月经后期（1至56天）。卵泡发育分别在53%、100%和100%的计日周期中发生。LH峰值分别在6%、75%和80%的周期中出现。潜在生育期分别在11/17（65%）和13/16（81%）的周期（2）和（3）中出现。潜在可育周期的比例在首次月经后以及产后6个月后更高。
一项基于EG测量的前瞻性检测预测了月经后期周期中13/15（85%）的潜在生育期。
