Hayashi S, Kiyokawa T, Aochi H, Nagamine K, Oshida M, Mizutani H, Tomiyama Y, Kurata Y
Department of Blood Transfusion, Osaka University Hospital Suita.
Rinsho Byori. 1996 Feb;44(2):169-75.
Using a panel of phospholipid(PL) antigens, we have established an enzyme linked immunosorbent assay (ELISA) for measuring both IgG and IgM type anti-phospholipid antibodies (APA) in sera from patients with systemic lupus erythematosus (SLE), idiopathic thrombocytopenic purpura (ITP) and recurrent fetal abortion (RFA). The percentage of anticardiolipin antibody (aCL) positive patients was increased in SLE (73% for IgG, 74% for IgM), ITP (24% for IgG, 8% for IgM) and RFA (20% for IgG, 52% for IgM) as compared with normal controls. The percentage of other APAs in each disease was significantly different from one another, suggesting the existence of disease-specific APA in these autoimmune disorders. We consider that it is important to analyze these APAs for the investigation of pathogenesis of autoimmune disorders.
我们使用一组磷脂（PL）抗原，建立了一种酶联免疫吸附测定（ELISA）方法，用于检测系统性红斑狼疮（SLE）、特发性血小板减少性紫癜（ITP）和复发性自然流产（RFA）患者血清中IgG和IgM型抗磷脂抗体（APA）。与正常对照相比，抗心磷脂抗体（aCL）阳性患者的比例在SLE（IgG为73%，IgM为74%）、ITP（IgG为24%，IgM为8%）和RFA（IgG为20%，IgM为52%）中均有所增加。每种疾病中其他APA的比例彼此之间有显著差异，表明这些自身免疫性疾病中存在疾病特异性APA。我们认为分析这些APA对于研究自身免疫性疾病的发病机制很重要。
