Krol W, Czuba Z, Scheller S, Paradowski Z, Shani J
Department of Microbiology and Immunology, Silesian School of Medicine, Zabrze-Rokitnica, Poland.
J Ethnopharmacol. 1994 Jan;41(1-2):121-6. doi: 10.1016/0378-8741(94)90066-3.
Fourteen flavonoids were evaluated for their ability to inhibit chemiluminescence, either of neutrophils that had been briefly exposed to both luminol and phorbol-myristate acetate or to an enzymatic system with H2O2, luminol and horseradish peroxidase. Using chemiluminescence as the quantitative parameter, it can be concluded that the hydroxyl group in position 3 of the flavonols is vital for their inhibitory effect, and that two hydroxyl groups on the phenyl ring are optimal for such an effect. It was also noted that the C2-C3 double bond is essential for the flavonols' anti-oxidative effect. It is suggested that the ability of flavonols to suppress chemiluminescence is reciprocally correlated with their lipophilicity.
