Czuba Z, Krol W, Scheller S, Shani J
Department of Microbiology, Silesian School of Medicine, Zabrze-Rokitnica, Poland.
Z Naturforsch C J Biosci. 1992 Sep-Oct;47(9-10):753-6. doi: 10.1515/znc-1992-9-1019.
Fourteen derivatives of cinnamic and acrylic acids were evaluated for their ability to modulate chemiluminescence, evoked by neutrophils that had been exposed to luminol and phorbol-myristate-acetate. Compounds with one or two hydroxyl groups on the phenyl ring demonstrated significant inhibition of the chemiluminescence, but this inhibition was diminished by methoxylation. Saturation of the double bond in the aliphatic chain of cinnamic acid at C6-enhanced the chemiluminescence to a small degree. All three acrylic acid derivatives demonstrated a marked inhibition of the luminol chemiluminescence, indicating that characteristics of the heterocyclic ring is of utmost importance in this activity.
对十四种肉桂酸和丙烯酸衍生物调节化学发光的能力进行了评估，该化学发光由暴露于鲁米诺和佛波醇-肉豆蔻酸酯-乙酸酯的中性粒细胞引发。苯环上带有一个或两个羟基的化合物对化学发光有显著抑制作用，但甲氧基化会减弱这种抑制作用。肉桂酸脂肪链中C6处双键的饱和在一定程度上增强了化学发光。所有三种丙烯酸衍生物对鲁米诺化学发光均表现出显著抑制作用，表明杂环的特性在该活性中至关重要。
