草苁蓉的自由基清除作用。

Radical scavenger effect of Boschniakia rossica.

作者信息

Tsuda T, Sugaya A, Liu Y Z, Katoh K, Tanaka H, Kawazura H, Sugaya E, Kusai M, Kohno M

机构信息

Faculty of Pharmaceutical Sciences, Josai University, Saitama-ken, Japan.

出版信息

J Ethnopharmacol. 1994 Jan;41(1-2):85-90. doi: 10.1016/0378-8741(94)90062-0.

DOI:10.1016/0378-8741(94)90062-0

PMID:8170164

Abstract

To elucidate the mechanism of the invigorating and antisenile action of the dried herb of Boschniakia rossica (Boschniakiae Herba), the free radical scavenging activity of its 50% ethanol extract (BR) was examined using an electron spin resonance spectrometer. The scavenging activity of plasma from Fisher-334 rats with continuous administration of BR was also examined. The concentrations showing 50% inhibition of the free radical of BR on the 1,1-diphenyl-2-picrylhydrazil (DPPH) radical, superoxide radical and hydroxyl radical were 0.003%, 0.06% and 9.67%, respectively. Plasma from the rats with BR administered clearly showed higher free radical scavenging activity compared with that of normal control rats. These findings suggest that Boschniakia rossica has strong free radical scavenging activity and consequently it has inhibitory effects on the disorders caused by free radical production in living tissue.

摘要

为阐明草苁蓉干燥全草的补益和抗衰老作用机制，采用电子自旋共振光谱仪检测了其50%乙醇提取物（BR）的自由基清除活性。还检测了连续给予BR的Fisher-334大鼠血浆的清除活性。BR对1,1-二苯基-2-苦基肼（DPPH）自由基、超氧阴离子自由基和羟自由基的自由基抑制率为50%时的浓度分别为0.003%、0.06%和9.67%。与正常对照大鼠相比，给予BR的大鼠血浆显示出更高的自由基清除活性。这些结果表明，草苁蓉具有较强的自由基清除活性，因此对活组织中自由基产生所引起的病症具有抑制作用。