Sasaki M, Ito M, Homma J Y
Jpn J Exp Med. 1975 Oct;45(5):335-43.
OEP--Original Endotoxin Protein--is a protein moiety of endotoxin of Pseudomonas aeruginosa. An adjuvant action of OEP was investigated in mice immunized with sheep red blood cells (SRBC). Several features characteristic of the adjuvant action of OEP have been revealed; OEP shows no effect on simultaneous treatment with the antigen, and is most effective on successive treatments given after SRBC. The effective dosages of OEP as an adjuvant were in the range of 10 to 100 mug per mouse. Experimental data suggested that OEP might enhance the antibody production in its early phase. The adjuvant action of OEP was lost in mice pretreated with large dosage of OEP; OEP-tolerance could be induced to its adjuvant action. The mechanism of the adjuvant action of OEP was discussed comparing with other adjuvants.
OEP（原始内毒素蛋白）是铜绿假单胞菌内毒素的一种蛋白质部分。在以绵羊红细胞（SRBC）免疫的小鼠中研究了OEP的佐剂作用。已揭示出OEP佐剂作用的几个特征；OEP对与抗原同时处理无作用，而对SRBC后进行的连续处理最有效。OEP作为佐剂的有效剂量为每只小鼠10至100微克。实验数据表明OEP可能在其早期增强抗体产生。用大剂量OEP预处理的小鼠中OEP的佐剂作用丧失；可以诱导对其佐剂作用的OEP耐受性。将OEP佐剂作用的机制与其他佐剂进行了比较讨论。
