Cohn M L, Robinson E D, Faerber M, Thomas D, Geyer S, Peters S, Martin M, Martin A, Sobel D, Jones R
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007.
Pediatr Infect Dis J. 1994 Jan;13(1):34-8.
The measles-specific antibody responses of seronegative adolescents and young adults were evaluated after revaccination. Of 1650 previously vaccinated healthy volunteers between the ages of 10 and 30 years, 4.4% were found to be seronegative for measles antibodies and 9.9% had equivocal titers. Seronegative volunteers were revaccinated to measles and followed serially for development of measles-specific IgG. Of 43 subjects followed for at least 1 year, only 58% developed and maintained positive antibody titers; 12% never developed positive titers and 30% initially developed titers that fell below positive levels within 1 year. The peak titers achieved by those subjects who responded transiently were lower than those achieved by subjects who developed sustained responses. Thus even after the recommended two dose schedule of the current measles vaccine, some adolescents and young adults lack protective titers of measles-specific antibody.
在再次接种疫苗后，对血清阴性的青少年和年轻成年人的麻疹特异性抗体反应进行了评估。在1650名年龄在10至30岁之间、之前已接种过疫苗的健康志愿者中，发现4.4%的人麻疹抗体呈血清阴性，9.9%的人滴度不明确。对血清阴性的志愿者进行了麻疹再次接种，并连续跟踪观察麻疹特异性IgG的产生情况。在43名至少随访1年的受试者中，只有58%的人产生并维持了阳性抗体滴度；12%的人从未产生阳性滴度，30%的人最初产生的滴度在1年内降至阳性水平以下。短暂反应的受试者所达到的峰值滴度低于产生持续反应的受试者。因此，即使按照目前麻疹疫苗推荐的两剂接种程序，一些青少年和年轻成年人仍缺乏具有保护作用的麻疹特异性抗体滴度。
