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逆转录病毒癌基因qin属于转录因子家族,该家族包括同源异型基因叉头。

The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head.

作者信息

Li J, Vogt P K

机构信息

Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033-1034.

出版信息

Proc Natl Acad Sci U S A. 1993 May 15;90(10):4490-4. doi: 10.1073/pnas.90.10.4490.

Abstract

Avian sarcoma virus 31 contains an oncogene that we have named qin. qin codes for a nuclear protein, Qin, that is a member of the HNF-3/fork head family of transcriptional regulators. Within this family Qin is particularly closely related to rat brain factor 1 (BF-1), a telencephalon-specific gene presumed to play an important role in the development of the mammalian brain.

摘要

禽肉瘤病毒31含有一个我们命名为qin的癌基因。qin编码一种核蛋白Qin,它是转录调节因子HNF-3/叉头家族的成员。在这个家族中,Qin与大鼠脑因子1(BF-1)特别密切相关,BF-1是一种假定在哺乳动物脑发育中起重要作用的端脑特异性基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2656/46537/c52c41db3580/pnas01462-0171-a.jpg

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