Cardon L R, Burge C, Clayton D A, Karlin S
Department of Mathematics, Stanford University, CA 94035.
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3799-803. doi: 10.1073/pnas.91.9.3799.
All available complete mitochondrial genomes (21 species) are evaluated for dinucleotide over- and under-representation. The CpG dinucleotide is pervasively under-represented in all animal mitochondria, but it is of variable relative abundance in fungal, protist, and plant mitochondrial genomes. Interpretations and hypotheses are considered relative to mitochondrial genome organization, methylation, structural specificities, directed mutation, and evolutionary events. In particular, our results support Mycoplasma capricolum or a close relative as the most likely bacterial ancestor of the mitochondria.
对所有可得的完整线粒体基因组（21个物种）进行二核苷酸过表达和低表达评估。CpG二核苷酸在所有动物线粒体中普遍低表达，但在真菌、原生生物和植物线粒体基因组中的相对丰度各不相同。结合线粒体基因组组织、甲基化、结构特异性、定向突变和进化事件对相关解释和假设进行了考量。特别是，我们的结果支持山羊支原体或其近亲是线粒体最有可能的细菌祖先。
