一种淋巴毒素-β特异性受体。
A lymphotoxin-beta-specific receptor.
作者信息
Crowe P D, VanArsdale T L, Walter B N, Ware C F, Hession C, Ehrenfels B, Browning J L, Din W S, Goodwin R G, Smith C A
机构信息
Division of Biomedical Sciences, University of California, Riverside 92521.
出版信息
Science. 1994 Apr 29;264(5159):707-10. doi: 10.1126/science.8171323.
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.
肿瘤坏死因子（TNF）和淋巴毒素-α（LT-α）是分泌型和细胞表面细胞因子家族的成员，它们参与免疫和炎症反应的调节。LT-α的细胞表面形式在生物合成过程中与淋巴毒素-β（LT-β）组装成异源三聚体复合物，LT-β是一种II型跨膜蛋白，也是TNF配体家族的另一个成员。分泌的LT-α是一种同三聚体，可与60和80千道尔顿的不同TNF受体结合；然而，这些受体不识别主要的细胞表面LT-α-LT-β复合物。已鉴定出一种对人LT-β特异的受体，这表明细胞表面LT可能具有与分泌的LT-α不同的功能。
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