Bert J, Vuillon-Cacciuttolo G, Balzamo E, De Micco P, Gambarelli D, Tamalet J, Gastaut H
Electroencephalogr Clin Neurophysiol. 1978 Nov;45(5):611-20. doi: 10.1016/0013-4694(78)90161-x.
EEG patterns recorded in the waking state and during sleep were studied in 6 rhesus monkeys inoculated with a strain of Kuru previously passaged in rhesus monkey (ENAGE strain, rhesus L6 56). The onset of the disease was confirmed by the appearance of various clinical signs in 4 monkeys 15 months after inoculation. At the 16th month, the first EEG modifications appeared during sleep, which became lighter. The waking EEG was abnormal during the mature phase of the disease; it was characterized by slow anomalies and scattered spikes. The sleep EEG still presented 3 stages of Slow Wave Sleep which, however, were totally unlike the physiological stages. REM sleep rapidly disappeared, as did the cyclic organization pattern. Irritative phenomena became very significant and, in particular, very frequent 'tonic seizures' were observed. Experimental Kuru thus appears, in the rhesus monkey, as an epileptogenic encephalopathy, which is differentiated from both the human disease and the experimental disease in the chimpanzee.
对6只接种了一株先前在恒河猴体内传代的库鲁病病毒(ENAGE毒株,恒河猴L6 56)的恒河猴,研究了其清醒状态和睡眠期间记录的脑电图模式。接种后15个月,4只猴子出现各种临床症状,确诊疾病发作。在第16个月,首次脑电图改变出现在睡眠期间,睡眠变得更浅。在疾病成熟阶段,清醒脑电图异常;其特征为慢波异常和散在棘波。睡眠脑电图仍呈现慢波睡眠的3个阶段,然而,这些阶段与生理阶段完全不同。快速眼动睡眠迅速消失,周期性组织模式也消失了。刺激性现象变得非常明显,特别是观察到非常频繁的“强直性发作”。因此,在恒河猴中,实验性库鲁病表现为一种致癫痫性脑病,它与人类疾病和黑猩猩的实验性疾病均有区别。