脑膜炎球菌性脑膜炎家族性免疫缺陷的证据。
Evidence for familial immune defect in meningococcal meningitis.
作者信息
Whittle H C, Oduloju A, Evans-Jones G, Greenwood B M
出版信息
Br Med J. 1976 May 22;1(6020):1247-50. doi: 10.1136/bmj.1.6020.1247.
Abstract
Twenty-six patients who had recovered from group A meningococcal meningitis were vaccinated with group C meningococcal polysaccharide and tetanus toxoid. Their haemagglutinating antibody response was measured two weeks later and compared with those of 22 siblings and 39 controls. Patients and siblings had a significantly lower antibody response to the group C vaccine but not to tetanus toxoid. This suggests that patients susceptible to meningococcal disease may have an immune defect involving their response to meningococcal polysaccharides.
摘要
26名从A群脑膜炎球菌性脑膜炎康复的患者接种了C群脑膜炎球菌多糖和破伤风类毒素。两周后测量了他们的血凝抗体反应，并与22名兄弟姐妹和39名对照者的反应进行了比较。患者和兄弟姐妹对C群疫苗的抗体反应明显较低，但对破伤风类毒素的反应并非如此。这表明易患脑膜炎球菌病的患者可能存在涉及对脑膜炎球菌多糖反应的免疫缺陷。
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