Hewitt B
Ultrasound Department, Royal Women's Hospital, Victoria, Australia.
Aust N Z J Obstet Gynaecol. 1993 Nov;33(4):389-91. doi: 10.1111/j.1479-828x.1993.tb02117.x.
All fetuses reported as having nuchal (nape of the neck) thickening or translucency detected by a first trimester ultrasound at 2 centres were reviewed to determine the incidence of aneuploidy. Twenty nine pregnancies were registered, amongst which 12 (41%) had an abnormal karyotype, the most common aneuploidy being trisomy 21 (5 fetuses). The likelihood of aneuploidy increased with increasing thickness of the translucency. Where the karyotype was found to be normal, there was complete resolution of this ultrasound appearance by the second trimester in 15 of the 16 ongoing pregnancies: 9 have delivered normal neonates and 6 pregnancies are continuing. The other fetus developed evidence of a skeletal dysplasia by the second trimester.
对在2个中心通过孕早期超声检查发现有颈部（颈后）增厚或半透明的所有胎儿进行了评估，以确定非整倍体的发生率。共登记了29例妊娠，其中12例（41%）核型异常，最常见的非整倍体是21-三体（5例胎儿）。非整倍体的可能性随着半透明厚度的增加而增加。在核型正常的情况下，16例继续妊娠中有15例在孕中期时这种超声表现完全消失：9例已分娩出正常新生儿，6例妊娠仍在继续。另1例胎儿在孕中期出现骨骼发育异常的迹象。
