Kim J J, St C Sinclair N R, Singhal S K, Carroll K K
Int Arch Allergy Appl Immunol. 1976;50(6):641-50. doi: 10.1159/000231542.
The effects of treatment of mice with an aqueous extract of Listeria monocytogenes on lymphoid populations and on immune responsiveness were studied. Thymus weight was decreased to a third of the control, whereas spleen weight was proportionally increased as the number of treatments was increased. The total numbers of cells in the thymus and bone marrow were diminished, whereas the number in the spleen was increased. Serum hemolysin production and plaque-forming cell response to sheep erythrocytes were suppressed in treated mice when the extract was given before administration of antigen. Spleen cells from treated mice failed to mount an antibody response upon transfer to syngeneic gamma-irradiated recipients, suggesting that potential antibody-producing cells were impaired by the treatment.
研究了用单核细胞增生李斯特菌水提取物处理小鼠对淋巴样细胞群和免疫反应性的影响。胸腺重量降至对照组的三分之一，而脾脏重量随着处理次数的增加而成比例增加。胸腺和骨髓中的细胞总数减少，而脾脏中的细胞数量增加。当在给予抗原之前给予提取物时，处理过的小鼠的血清溶血素产生和对绵羊红细胞的空斑形成细胞反应受到抑制。将处理过的小鼠的脾细胞转移到同基因γ射线照射的受体后，未能产生抗体反应，这表明潜在的抗体产生细胞受到了处理的损害。
