Ardawi M S, Nasrat H A, Bahnassy A A
Department of Clinical Biochemistry, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Diabet Med. 1994 Jan-Feb;11(1):50-6. doi: 10.1111/j.1464-5491.1994.tb00229.x.
The effect of various grades of obesity on serum fructosamine concentrations was studied in Type 2 diabetic (n = 105) and non-diabetic (n = 128) subjects. In obese diabetic and non-diabetic subjects (body mass index > or = 30 kg m-2), the concentration of fructosamine was markedly lower than that obtained for lean diabetic and non-diabetic subjects with similar glycaemic control. Stepwise multiple-regression analysis showed that fructosamine was associated with glycaemic control (as indicated by fasting plasma glucose and glycated haemoglobin), fasting triglycerides, and body mass index in both diabetic and non-diabetic subjects. In vitro studies showed marked decreases in both the extent of [14C]-glucose incorporation into plasma proteins and fructosamine production by incubated sera of obese patients whether diabetic or non-diabetic, with obese subjects with body mass index > 40 kg m-2 exhibiting the greatest decrease. In conclusion, serum fructosamine concentrations are shown to decrease in obese diabetic and non-diabetic subjects with body mass index > or = 30 kg m-2 giving rise to the underestimation of glycaemic control as indicated by fructosamine measurement. A change in the glycation reaction itself may be partly responsible for such decrease.
在2型糖尿病患者（n = 105）和非糖尿病患者（n = 128）中研究了不同程度肥胖对血清果糖胺浓度的影响。在肥胖的糖尿病患者和非糖尿病患者（体重指数≥30 kg/m²）中，果糖胺浓度明显低于血糖控制相似的消瘦糖尿病患者和非糖尿病患者。逐步多元回归分析表明，在糖尿病患者和非糖尿病患者中，果糖胺与血糖控制（以空腹血糖和糖化血红蛋白表示）、空腹甘油三酯和体重指数相关。体外研究表明，无论是糖尿病肥胖患者还是非糖尿病肥胖患者，其血清中[¹⁴C] - 葡萄糖掺入血浆蛋白的程度和果糖胺的生成均显著降低，体重指数> 40 kg/m²的肥胖受试者下降最为明显。总之，体重指数≥30 kg/m²的肥胖糖尿病患者和非糖尿病患者血清果糖胺浓度降低，导致果糖胺测量结果低估血糖控制情况。糖化反应本身的变化可能部分导致了这种降低。
