Kim D H, Muthyala S, Soliven B, Wiegmann K, Wollmann R, Chelmicka-Schorr E
Department of Neurology, University of Chicago, IL 60637.
J Neuroimmunol. 1994 May;51(2):177-83. doi: 10.1016/0165-5728(94)90079-5.
Treatment of rats with experimental allergic neuritis with the beta 2-adrenergic agonist terbutaline suppresses clinical symptoms, decreases demyelination and Wallerian degeneration in peripheral nerves and improves electrophysiological parameters. Treatment is highly effective when given from the time of immunization through the acute phase of illness, when given for the first 12 days after immunization and also when given after the onset of the disease.
用β2 - 肾上腺素能激动剂特布他林治疗实验性变态反应性神经炎大鼠,可抑制临床症状,减少外周神经的脱髓鞘和华勒变性,并改善电生理参数。从免疫时起至疾病急性期给药、免疫后前12天给药以及在疾病发作后给药,治疗均非常有效。