Gomez J E, Thurston G B
Department of Pediatrics, University of Texas Health Science Center at San Antonio 78284.
Biorheology. 1993 Sep-Dec;30(5-6):409-27. doi: 10.3233/bir-1993-305-612.
Rheological and compositional properties of pathological synovial fluids were measured and compared in order to reveal differences between disease states. The cases include degenerative joint disease, rheumatoid arthritis, mixed connective tissue disease, and pseudogout. Using an oscillatory flow capillary instrument, measurements were made of both the frequency and shear rate dependence of the complex viscoelasticity. The fluid types differ most in their elasticity, with the degenerative joint disease fluids having the greatest average viscosity, elasticity and intrinsic viscosity, followed by the rheumatoid arthritis fluids, and the fluids from cases of mixed connective tissue disease. Differences in the hyaluronate and protein concentrations are not as great as those between rheological variables. The viscoelasticity of synovial fluid appears more strongly dependent on the degree of polymerization of hyaluronate than on its concentration. These synovial fluids conform well to a model of relaxation process truncation. Distinct types of elastic stress-strain behavior reveal the nature of the dynamic fluid structure.
为了揭示不同疾病状态之间的差异，对病理性滑液的流变学和成分特性进行了测量和比较。这些病例包括退行性关节病、类风湿性关节炎、混合性结缔组织病和假性痛风。使用振荡流毛细管仪器，对复合粘弹性的频率和剪切速率依赖性进行了测量。不同类型的滑液在弹性方面差异最大，退行性关节病滑液的平均粘度、弹性和特性粘度最高，其次是类风湿性关节炎滑液，然后是混合性结缔组织病病例的滑液。透明质酸盐和蛋白质浓度的差异不如流变学变量之间的差异大。滑液的粘弹性似乎更强烈地依赖于透明质酸盐的聚合程度而不是其浓度。这些滑液与弛豫过程截断模型非常吻合。不同类型的弹性应力-应变行为揭示了动态流体结构的本质。
