Wong T Y, Mihm M C
Dermatopathology Division, Massachusetts General Hospital, Harvard Medical School.
J Cutan Pathol. 1994 Feb;21(1):27-32. doi: 10.1111/j.1600-0560.1994.tb00687.x.
A series of 3 cases of acantholytic dermatosis localized to the male genitalia and perineal area with distinct clinical and histological features is presented. These patients did not have a family history of similar disorders and had no evidence of rash elsewhere. Clinically, the eruption was characterized by multiple discrete papules or macerated patches involving the genitalia and the perineum. Histologically, the acantholytic dermatosis had features that resembled both Hailey-Hailey disease and Darier's disease. Similar clinical and histological findings have been reported in females. To the best of our knowledge, this is the first report of these lesions described confined to the genital and perineal areas in male patients. We agree with other authors that this condition may represent a distinct acantholytic eruption in the perineal area that should be distinguished from other generalized blistering acantholytic dyskeratotic disorders that may also involve the genitalia.
本文报告了3例局限于男性生殖器和会阴区域的棘层松解性皮肤病，具有独特的临床和组织学特征。这些患者没有类似疾病的家族史，身体其他部位也没有皮疹迹象。临床上，皮疹表现为累及生殖器和会阴的多个离散丘疹或浸渍斑。组织学上，棘层松解性皮肤病具有类似家族性良性慢性天疱疮和毛囊角化病的特征。女性也有类似的临床和组织学表现报道。据我们所知，这是首次报道男性患者局限于生殖器和会阴区域的此类病变。我们同意其他作者的观点，即这种情况可能代表会阴区域一种独特的棘层松解性皮疹，应与其他也可能累及生殖器的全身性水疱性棘层松解性角化不良性疾病相鉴别。
