Enden G, Popel A S
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
J Biomech Eng. 1994 Feb;116(1):79-88. doi: 10.1115/1.2895708.
Owing in part to a plasma-skimming mechanism, the distribution of red blood cells (RBCs) into branches of microvascular bifurcations typically differs from the distribution of the bulk blood flow. This paper analyzes the plasma-skimming mechanism that causes phase separation due to uneven distribution of red blood cells at the inlet cross section of the parent vessel. In a previous study, the shape of the surface that divides the flow into the branches was found by numerical simulation of three-dimensional flow of a homogeneous Newtonian fluid in T-type bifurcations. Those findings are used in this study to determine, as a first approximation, the side-to-parent vessel RBC flux ratio and discharge hematocrit ratio as a function of corresponding flow ratios. Calculations are based on the assumption that RBCs move along streamlines of a homogeneous Newtonian fluid and are uniformly distributed within a concentric core at the inlet cross section of the parent vessel. The results of our calculations agree well for a wide range of flow parameters with experimental data from in vivo and in vitro studies.
部分由于血浆撇除机制，红细胞（RBC）在微血管分支中的分布通常不同于总体血流的分布。本文分析了由于红细胞在母血管入口横截面分布不均而导致相分离的血浆撇除机制。在先前的一项研究中，通过对T型分支中均匀牛顿流体的三维流动进行数值模拟，发现了将流体分为分支的表面形状。本研究利用这些发现作为初步近似，确定侧支与母血管的红细胞通量比和排出血细胞比作为相应流量比的函数。计算基于以下假设：红细胞沿着均匀牛顿流体的流线移动，并在母血管入口横截面的同心核心内均匀分布。我们的计算结果在广泛的流动参数范围内与体内和体外研究的实验数据吻合良好。
