Brunser O, Espinoza J, Araya M, Cruchet S, Gil A
Gastroenterology Unit, University of Chile, Santiago.
Acta Paediatr. 1994 Feb;83(2):188-91. doi: 10.1111/j.1651-2227.1994.tb13048.x.
The effects of a nucleotide-supplemented formula on diarrhoeal disease was studied in 141 infants (group 1) who belonged to the low socioeconomic stratum; 148 controls (group 2) received the same formula but unsupplemented. Group 1 experienced less episodes of diarrhoea (109 versus 140), including less first episodes (74 versus 102; chi-square = 8.19, p < 0.004; odds ratio 2.01) and for a lesser number of days (807 versus 996 days); 45.0% and 31.1% of infants in groups 1 and 2, respectively, never developed episodes of diarrhoea. There were no differences in the clinical characteristics of the episodes or in the enteropathogens isolated from symptomatic or asymptomatic infants. The mechanisms through which nucleotides decrease the incidence of diarrhoeal disease in infants remain unclear.
在141名来自低社会经济阶层的婴儿（第1组）中研究了添加核苷酸的配方奶粉对腹泻病的影响；148名对照组婴儿（第2组）接受相同的未添加核苷酸的配方奶粉。第1组腹泻发作次数较少（109次对140次），包括首次发作次数较少（74次对102次；卡方 = 8.19，p < 0.004；优势比2.01），且腹泻天数较少（807天对996天）；第1组和第2组分别有45.0%和31.1%的婴儿从未发生过腹泻发作。腹泻发作的临床特征或从有症状或无症状婴儿中分离出的肠道病原体没有差异。核苷酸降低婴儿腹泻病发病率的机制尚不清楚。
