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在霍乱弧菌小川O1血清型脂多糖中鉴定出一种新型糖类,4-氨基-4,6-二脱氧-2-O-甲基甘露糖。

Identification of a novel sugar, 4-amino-4,6-dideoxy-2-O-methylmannose in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa.

作者信息

Ito T, Higuchi T, Hirobe M, Hiramatsu K, Yokota T

机构信息

Department of Bacteriology, School of Medicine, Juntendo University, Tokyo, Japan.

出版信息

Carbohydr Res. 1994 Mar 18;256(1):113-28. doi: 10.1016/0008-6215(94)84231-0.

Abstract

A novel sugar in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa has been identified. The sugar was liberated from the lipopolysaccharide when hydrolyzed in 10 M HCl at 90 degrees C for 15 min. The sugar was purified and identified as 4-amino-4,6-dideoxy-2-O-methylmannose (2-O-methylperosamine). Since it was found only in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa, it seems that the sugar is one of the specific constituents determining Ogawa serotype specificity.

摘要

已鉴定出霍乱弧菌小川O1血清型脂多糖中的一种新型糖。该糖在90℃下于10M盐酸中水解15分钟时从脂多糖中释放出来。该糖经纯化后被鉴定为4-氨基-4,6-二脱氧-2-O-甲基甘露糖(2-O-甲基过氧胺)。由于仅在霍乱弧菌小川O1血清型的脂多糖中发现了这种糖,因此该糖似乎是决定小川血清型特异性的特定成分之一。

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