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1
Primary structures of the wild-type and mutant alleles encoding the phosphatidylglycerophosphate synthase of Escherichia coli.编码大肠杆菌磷脂酰甘油磷酸合酶的野生型和突变等位基因的一级结构。
J Bacteriol. 1994 Jun;176(11):3389-92. doi: 10.1128/jb.176.11.3389-3392.1994.
2
Isolation and expression of the Rhodobacter sphaeroides gene (pgsA) encoding phosphatidylglycerophosphate synthase.球形红杆菌中编码磷脂酰甘油磷酸合酶的基因（pgsA）的分离与表达
J Bacteriol. 1996 Feb;178(4):1030-8. doi: 10.1128/jb.178.4.1030-1038.1996.
3
Overexpression of phosphatidylglycerophosphate synthase restores protein translocation in a secG deletion mutant of Escherichia coli at low temperature.磷脂酰甘油磷酸合酶的过表达可在低温下恢复大肠杆菌secG缺失突变体中的蛋白质转运。
FEBS Lett. 1995 May 8;364(2):157-60. doi: 10.1016/0014-5793(95)00378-m.
4
Identification of proteins whose amounts are altered by mutation in the pgsA gene of Escherichia coli.鉴定其含量因大肠杆菌pgsA基因突变而改变的蛋白质。
Biol Pharm Bull. 1998 Nov;21(11):1139-41. doi: 10.1248/bpb.21.1139.
5
Structure and expression of the gene locus encoding the phosphatidylglycerophosphate synthase of Escherichia coli.编码大肠杆菌磷脂酰甘油磷酸合酶的基因位点的结构与表达
J Biol Chem. 1986 Jan 25;261(3):1329-38.
6
Isolation of a chinese hamster ovary (CHO) cDNA encoding phosphatidylglycerophosphate (PGP) synthase, expression of which corrects the mitochondrial abnormalities of a PGP synthase-defective mutant of CHO-K1 cells.编码磷脂酰甘油磷酸（PGP）合酶的中国仓鼠卵巢（CHO）cDNA的分离，其表达可纠正CHO-K1细胞的PGP合酶缺陷型突变体的线粒体异常。
J Biol Chem. 1999 Jan 15;274(3):1828-34. doi: 10.1074/jbc.274.3.1828.
7
Viability of an Escherichia coli pgsA null mutant lacking detectable phosphatidylglycerol and cardiolipin.缺乏可检测到的磷脂酰甘油和心磷脂的大肠杆菌pgsA基因敲除突变体的生存能力。
J Bacteriol. 2000 Jan;182(2):371-6. doi: 10.1128/JB.182.2.371-376.2000.
8
Growth phenotypes of Escherichia coli carrying a mutation of acidic phospholipid synthesis.携带酸性磷脂合成突变的大肠杆菌的生长表型
Biol Pharm Bull. 1996 Oct;19(10):1275-8. doi: 10.1248/bpb.19.1275.
9
Suppression of the lethal effect of acidic-phospholipid deficiency by defective formation of the major outer membrane lipoprotein in Escherichia coli.大肠杆菌中主要外膜脂蛋白形成缺陷对酸性磷脂缺乏致死效应的抑制作用。
J Bacteriol. 1989 Dec;171(12):6867-9. doi: 10.1128/jb.171.12.6867-6869.1989.
10
Envelope disorder of Escherichia coli cells lacking phosphatidylglycerol.缺乏磷脂酰甘油的大肠杆菌细胞的包膜紊乱
J Bacteriol. 2002 Oct;184(19):5418-25. doi: 10.1128/JB.184.19.5418-5425.2002.

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1
Mutations in and Correlate with Daptomycin Resistance in and .和 突变与 和 中的达托霉素耐药性相关。
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2
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4
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6
Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo.体内遗传证据表明大肠杆菌信号识别颗粒受体与酸性脂之间存在功能相互作用。
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7
Overproduction or absence of the periplasmic protease DegP severely compromises bacterial growth in the absence of the dithiol: disulfide oxidoreductase DsbA.在缺乏二硫醇：二硫化物氧化还原酶DsbA的情况下，周质蛋白酶DegP的过量产生或缺失会严重损害细菌生长。
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8
Cloning and characterization of the phosphatidylserine synthase gene of Agrobacterium sp. strain ATCC 31749 and effect of its inactivation on production of high-molecular-mass (1-->3)-beta-D-glucan (curdlan).土壤杆菌属菌株ATCC 31749磷脂酰丝氨酸合酶基因的克隆与特性分析及其失活对高分子量（1→3）-β-D-葡聚糖（凝胶多糖）产量的影响
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9
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10
Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli.yccL（gnsA）和ydfY（gnsB）的过表达会增加不饱和脂肪酸的水平，并抑制大肠杆菌的温度敏感型fabA6突变和冷敏感型secG缺失突变。
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本文引用的文献

1
Two interacting mutations causing temperature-sensitive phosphatidylglycerol synthesis in Escherichia coli membranes.两个相互作用的突变导致大肠杆菌细胞膜中温度敏感型磷脂酰甘油的合成。
J Bacteriol. 1981 Jan;145(1):113-21. doi: 10.1128/jb.145.1.113-121.1981.
2
Cloning of genes involved in membrane lipid synthesis: effects of amplification of phosphatidylglycerophosphate synthase in Escherichia coli.参与膜脂合成的基因克隆：大肠杆菌中磷脂酰甘油磷酸合酶扩增的影响
J Bacteriol. 1981 Aug;147(2):552-62. doi: 10.1128/jb.147.2.552-562.1981.
3
Phosphatidic acid accumulation in the membranes of Escherichia coli mutants defective in CDP-diglyceride synthetase.磷脂酸在CDP - 甘油二酯合成酶缺陷的大肠杆菌突变体膜中的积累。
J Biol Chem. 1980 Feb 25;255(4):1623-9.
4
Phosphatidylserine synthesis in Saccharomyces cerevisiae. Purification and characterization of membrane-associated phosphatidylserine synthase.酿酒酵母中的磷脂酰丝氨酸合成。膜相关磷脂酰丝氨酸合酶的纯化与特性分析。
J Biol Chem. 1984 Sep 10;259(17):10857-62.
5
Improved single and multicopy lac-based cloning vectors for protein and operon fusions.用于蛋白质和操纵子融合的改进型基于乳糖操纵子的单拷贝和多拷贝克隆载体。
Gene. 1987;53(1):85-96. doi: 10.1016/0378-1119(87)90095-3.
6
Regulation of the balanced synthesis of membrane phospholipids. Experimental test of models for regulation in Escherichia coli.膜磷脂平衡合成的调控。大肠杆菌中调控模型的实验测试。
J Biol Chem. 1986 Oct 15;261(29):13464-8.
7
Construction of a lethal mutation in the synthesis of the major acidic phospholipids of Escherichia coli.在大肠杆菌主要酸性磷脂合成中构建致死突变。
J Biol Chem. 1987 Sep 25;262(27):13044-9.
8
Mutations affecting translation of the bacteriophage T4 rIIB gene cloned in Escherichia coli.影响克隆于大肠杆菌中的噬菌体T4 rIIB基因翻译的突变。
Mol Gen Genet. 1987 May;207(2-3):224-32. doi: 10.1007/BF00331582.
9
Nucleotide sequence and characterization of the yeast PSS gene encoding phosphatidylserine synthase.编码磷脂酰丝氨酸合酶的酵母PSS基因的核苷酸序列及特性分析
Eur J Biochem. 1987 Aug 17;167(1):7-12. doi: 10.1111/j.1432-1033.1987.tb13297.x.
10
Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.酿酒酵母磷脂酰肌醇合酶基因的一级结构与破坏
J Biol Chem. 1987 Apr 5;262(10):4876-81.

编码大肠杆菌磷脂酰甘油磷酸合酶的野生型和突变等位基因的一级结构。

Primary structures of the wild-type and mutant alleles encoding the phosphatidylglycerophosphate synthase of Escherichia coli.

作者信息

Usui M, Sembongi H, Matsuzaki H, Matsumoto K, Shibuya I

机构信息

Department of Biochemistry, Saitama University, Urawa, Japan.

出版信息

J Bacteriol. 1994 Jun;176(11):3389-92. doi: 10.1128/jb.176.11.3389-3392.1994.

DOI:10.1128/jb.176.11.3389-3392.1994
PMID:8195097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC205513/
Abstract

The nucleotide sequence of the Escherichia coli pgsA gene, encoding phosphatidylglycerophosphate synthase, is revised to code for an enzyme of 182 amino acid residues, instead of the 216 of a previous work (A. S. Gopalakrishnan, Y.-C. Chen, M. Temkin, and W. Dowhan, J. Biol. Chem. 261:1329-1338, 1986). The revised structure now explains the properties of the enzyme. Three pgsA mutants of different phenotypes were also analyzed: pgsA3, pgsA36, and pgsA10 have single-base replacements in codons 60 (Thr-->Pro), 1 (ATG-->ATA), and 92 (Thr-->Ile), respectively.

摘要

编码磷脂酰甘油磷酸合酶的大肠杆菌pgsA基因的核苷酸序列经修订后编码一种由182个氨基酸残基组成的酶，而非先前研究（A. S. 戈帕拉克里什南、Y.-C. 陈、M. 坦金和W. 多曼，《生物化学杂志》261:1329 - 1338, 1986）中所报道的216个氨基酸残基。修订后的结构如今解释了该酶的特性。还对三个不同表型的pgsA突变体进行了分析：pgsA3、pgsA36和pgsA10分别在密码子60（苏氨酸→脯氨酸）、1（ATG→ATA）和92（苏氨酸→异亮氨酸）处发生了单碱基替换。