Mahmoud E A, Hamad E E, Olsson S E, Mårdh P A
Institute of Clinical Bacteriology, University of Uppsala, Sweden.
Contraception. 1994 Mar;49(3):265-74. doi: 10.1016/0010-7824(94)90044-2.
Cervical secretion from three groups of asymptomatic women, either being oral contraceptive (OC) non-users or users (ethinylestradiol plus desogestrel or levonorgestrel), was tested for its capacity to prevent Chlamydia trachomatis, serotype I, from forming inclusions in cycloheximide-treated McCoy cells. The non-user groups were comprised of 12 women from whom cervical secretion was collected twice weekly during the menstrual cycle and 15 women from whom cervical secretion was collected once or twice weekly. The OC users included 66 women from whom cervical secretion was collected once or twice during their menstrual cycle. Cervical secretion from the non-users produced a decrease in the chlamydial inclusion count by 70%-90% during the first 3 weeks of the menstrual cycle, as compared with the fourth and fifth week when the reduction was 56%-68% (p < 0.001). Secretion from the OC users showed a more effective decrease in the inclusion count during the first 3 weeks of the menstrual cycle, as compared with samples obtained at the fourth and fifth weeks, i.e. 15%-35% vs. 20%-25% (p < 0.001). Cervical secretion of the non-users as compared to the users produced a significant decrease in the inclusion count, viz. 70%-90% vs. 15%-35% (p < 0.001) during the first 3 weeks as compared with 56%-68% vs. 20%-25% (p < 0.001) in the fourth or fifth week. The study suggests that natural resistance to genital chlamydial infection can differ during the menstrual cycle and it may be influenced by oral contraceptive use.
对三组无症状女性的宫颈分泌物进行了检测，这三组女性分别为未使用口服避孕药（OC）者以及使用者（炔雌醇加去氧孕烯或左炔诺孕酮），检测其阻止沙眼衣原体I型在经环己酰亚胺处理的 McCoy 细胞中形成包涵体的能力。未使用者组包括 12 名女性，在月经周期中每周两次收集她们的宫颈分泌物，还有 15 名女性，每周一次或两次收集她们的宫颈分泌物。口服避孕药使用者包括 66 名女性，在月经周期中收集她们的宫颈分泌物一到两次。与月经周期第四周和第五周相比，未使用者的宫颈分泌物在月经周期的前三周使衣原体包涵体数量减少了 70%-90%，而第四周和第五周的减少率为 56%-68%（p<0.001）。与在第四周和第五周获得的样本相比，口服避孕药使用者的分泌物在月经周期的前三周对包涵体数量的减少更有效，即分别为 15%-35% 与 20%-25%（p<0.001）。与使用者相比，未使用者的宫颈分泌物在包涵体数量上有显著减少，即前三周为 70%-90% 与 15%-35%（p<0.001），第四周或第五周为 56%-68% 与 20%-25%（p<0.001）。该研究表明，对生殖道衣原体感染的天然抵抗力在月经周期中可能不同，并且可能受到口服避孕药使用的影响。
