Broughton R, Stuss D, Kates M, Roberts J, Dunham W
Division of Neurology, Ottawa General Hospital, Ontario, Canada.
Can J Neurol Sci. 1990 Nov;17(4):410-5. doi: 10.1017/s0317167100030985.
Eight patients with myotonic dystrophy underwent comprehensive neuropsychological testing and overnight polysomnography to assess whether the waking cognitive impairment might be attributable to sleep structure abnormalities or to sleep-related respiratory problems. Patients showed substantial neuropsychological deficits, fragmented nocturnal sleep and, in half the patients, sleep apnea and/or hypopnea both mainly of central type. There was no statistically significant correlation between the degree of daytime cognitive deficit and the degree of sleep fragmentation or of respiratory problems at night. It was concluded that the neuropsychological deficit in mytonic dystrophy cannot be attributed to a secondary effect of nocturnal sleep apnea or sleep disruption but probably represents a direct effect of CNS lesions.
八名强直性肌营养不良患者接受了全面的神经心理学测试和夜间多导睡眠监测，以评估清醒时的认知障碍是否可能归因于睡眠结构异常或与睡眠相关的呼吸问题。患者表现出明显的神经心理学缺陷、夜间睡眠碎片化，并且一半的患者存在睡眠呼吸暂停和/或呼吸浅慢，主要为中枢型。白天认知缺陷程度与夜间睡眠碎片化程度或呼吸问题程度之间没有统计学上的显著相关性。得出的结论是，强直性肌营养不良中的神经心理学缺陷不能归因于夜间睡眠呼吸暂停或睡眠中断的继发效应，而可能代表中枢神经系统病变的直接效应。
