National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, 080-8555, Obihiro, Hokkaido, Japan.
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt.
Biomolecules. 2020 Feb 25;10(3):352. doi: 10.3390/biom10030352.
Traditional herbal remedies have been attracting attention as prospective alternative resources of therapy for diverse diseases across many nations. In recent decades, medicinal plants have been gaining wider acceptance due to the perception that these plants, as natural products, have fewer side effects and improved efficacy compared to their synthetic counterparts. L. (Licorice) is a small perennial herb that has been traditionally used to treat many diseases, such as respiratory disorders, hyperdipsia, epilepsy, fever, sexual debility, paralysis, stomach ulcers, rheumatism, skin diseases, hemorrhagic diseases, and jaundice. Moreover, chemical analysis of the extracts revealed the presence of several organic acids, liquirtin, rhamnoliquirilin, liquiritigenin, prenyllicoflavone A, glucoliquiritin apioside, 1-metho-xyphaseolin, shinpterocarpin, shinflavanone, licopyranocoumarin, glisoflavone, licoarylcoumarin, glycyrrhizin, isoangustone A, semilicoisoflavone B, licoriphenone, and 1-methoxyficifolinol, kanzonol R and several volatile components. Pharmacological activities of have been evaluated against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium falciparum, and completely eradicated P. yoelii parasites. Additionally, it shows antioxidant, antifungal, anticarcinogenic, anti-inflammatory, and cytotoxic activities. The current review examined the phytochemical composition, pharmacological activities, pharmacokinetics, and toxic activities of extracts as well as its phytoconstituents.
传统草药作为治疗多种疾病的潜在替代资源，在许多国家引起了关注。近几十年来，由于人们认为这些植物作为天然产品，与合成药物相比，副作用更少，疗效更好，药用植物得到了更广泛的认可。甘草（Licorice）是一种小型多年生草本植物，传统上用于治疗多种疾病，如呼吸障碍、口渴、癫痫、发热、性功能减退、瘫痪、胃溃疡、风湿病、皮肤病、出血性疾病和黄疸。此外，对提取物的化学分析表明存在几种有机酸、甘草素、鼠李糖苷、甘草素、prenyllicoflavone A、glucoliquiritin apioside、1-metho-xyphaseolin、shinpterocarpin、shinflavanone、licopyranocoumarin、glisoflavone、licoarylcoumarin、glycyrrhizin、isoangustone A、semilicoisoflavone B、licoriphenone 和 1-methoxyficifolinol、kanzonol R 和几种挥发性成分。甘草的药理活性已针对各种微生物和寄生虫进行了评估，包括致病菌、病毒和恶性疟原虫，并完全根除了疟原虫。此外，它还具有抗氧化、抗真菌、抗癌、抗炎和细胞毒性活性。本综述检查了甘草提取物及其植物成分的植物化学成分、药理活性、药代动力学和毒理活性。
