Pereira N A, Pereira B M, do Nascimento M C, Parente J P, Mors W B
Departamento de Farmacologia, CCS-ICB, Universidade Federal do Rio de Janeiro, Brasil.
Planta Med. 1994 Apr;60(2):99-100.
Fifteen compounds, isolated from plants reputed as snake venom antidotes, belonging to different classes of natural products, were shown to protect mice to a significant degree against the lethal action of the venom of Bothrops jararaca snakes. Administration was by the oral route, one hour prior to envenomation. The substances are nitrogen-free, low-molecular-weight compounds for which some kind of biodynamic activity has previously been reported. The fact that they are mostly trivial, naturally-occurring compounds should explain why plants used as snake-bite antidotes are so widely distributed over the plant kingdom.
从被认为是蛇毒解毒剂的植物中分离出的15种化合物，属于不同类别的天然产物，已被证明能在很大程度上保护小鼠免受巴西矛头蝮蛇毒液的致命作用。给药途径为口服，在注入毒液前一小时进行。这些物质是无氮的低分子量化合物，此前已报道过它们具有某种生物动力学活性。它们大多是常见的天然化合物，这一事实应该可以解释为什么用作蛇咬解毒剂的植物在植物界分布如此广泛。
