在严重急性哮喘中，雾化沙丁胺醇加用氨茶碱静脉滴注的效果。
Effect of adding aminophylline infusion to nebulised salbutamol in severe acute asthma.
作者信息
Zainudin B M, Ismail O, Yusoff K
机构信息
Department of Medicine, University Kebangsaan Malaysia, Kuala Lumpur.
出版信息
Thorax. 1994 Mar;49(3):267-9. doi: 10.1136/thx.49.3.267.
Abstract
BACKGROUND
The benefit of adding theophylline to beta 2 agonists in acute asthmatic attacks has been debated frequently.
METHODS
In an open randomised study 25 patients with severe acute asthma who presented to the emergency department were treated with either a combined nebulised salbutamol (5 mg/dose) and aminophylline infusion (0.6-0.9 mg/kg/hour), or nebulised salbutamol alone.
RESULTS
The responses to treatment as measured by peak expiratory flow (PEF) and the time taken to achieve maximum PEF were similar in both groups. Side effects were observed more commonly in patients receiving the combined treatment.
CONCLUSIONS
Nebulised salbutamol is equally efficacious in acute asthma when given alone or in combination with aminophylline.
摘要
背景
在急性哮喘发作时，将茶碱添加到β2受体激动剂中是否有益一直存在争议。
方法
在一项开放性随机研究中，25名到急诊科就诊的重度急性哮喘患者，分别接受联合雾化沙丁胺醇（5毫克/剂量）和氨茶碱静脉输注（0.6 - 0.9毫克/千克/小时）治疗，或仅接受雾化沙丁胺醇治疗。
结果
两组患者以呼气峰值流速（PEF）衡量的治疗反应以及达到最大PEF所需时间相似。联合治疗组患者更常观察到副作用。
结论
单独使用或与氨茶碱联合使用时，雾化沙丁胺醇在急性哮喘治疗中疗效相同。
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