Jongeneelen F J
Toxicol Lett. 1994 Jun;72(1-3):205-11. doi: 10.1016/0378-4274(94)90030-2.
A biomarker of human exposure to chemical agents provides a valuable parameter for assessing the extent and significance of the uptake by giving a measurement that is direct and integrated over time and exposure routes. Urinary 1-hydroxypyrene is currently tested as a biomarker for the assessment of low level environmental exposure of people to polycyclic aromatic hydrocarbons (PAH). Five examples of the application of urinary 1-hydroxypyrene methodology in the assessment of environmental exposure to PAH are presented: inhalation of tobacco smoke; inhalation of urban outdoor air; windsurfers sailing on polluted water; absorption of contaminated food; exposure in an urban area with many heavy industries. The examples illustrate that the urinary 1-hydroxypyrene test is sufficiently sensitive. Urinary 1-hydroxypyrene is an effective biomarker for the assessment of human environmental exposure to PAH.
人体接触化学物质的生物标志物通过提供一个直接且随时间和接触途径综合测量的数值，为评估摄取的程度和重要性提供了一个有价值的参数。尿中1-羟基芘目前作为一种生物标志物，用于评估人群对多环芳烃（PAH）的低水平环境暴露。本文介绍了尿中1-羟基芘方法在评估PAH环境暴露中的五个应用实例：吸入烟草烟雾；吸入城市室外空气；在受污染水域风帆冲浪；摄入受污染食物；在有许多重工业的城区暴露。这些实例表明，尿中1-羟基芘检测具有足够的敏感性。尿中1-羟基芘是评估人类对PAH环境暴露的有效生物标志物。
