Jacob Jürgen, Seidel Albrecht
Biochemisches Institut für Umweltcarcinogene-Prof Dr Gernot Grimmer-Stiftung, Lurup 4, D-22927 Grosshansdorf, Germany.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):31-47. doi: 10.1016/s0378-4347(01)00467-4.
Measurement of polycyclic aromatic hydrocarbons (PAH) metabolites in human urine is the method of choice to determine occupational and/or environmental exposure of an individual to PAH, in particular, when multiple routes of exposure have to be taken into account. Requirements for methods of biomonitoring PAH metabolites in urine are presented. Studies using 1-hydroxypyrene or phenanthrene metabolites including its phenols and dihydrodiols are summarized. The role of these PAH metabolites as established biomarkers and also more recent developments of PAH biomonitoring are discussed.
测定人体尿液中的多环芳烃（PAH）代谢物是确定个体职业和/或环境中PAH暴露情况的首选方法，尤其是在需要考虑多种暴露途径时。本文提出了尿液中PAH代谢物生物监测方法的要求。总结了使用1-羟基芘或菲代谢物（包括其酚类和二氢二醇）的研究。讨论了这些PAH代谢物作为既定生物标志物的作用以及PAH生物监测的最新进展。
