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反搏:历史背景、技术改进、血流动力学及代谢效应

Counterpulsation: historical background, technical improvements, hemodynamic and metabolic effects.

作者信息

Nanas J N, Moulopoulos S D

机构信息

University of Athens School of Medicine, Department of Clinical Therapeutics, Alexandra Hospital, Greece.

出版信息

Cardiology. 1994;84(3):156-67. doi: 10.1159/000176394.

Abstract

The intraaortic balloon counterpulsation is performed today on the same principles that were described in its first experimental use in 1962. Experimental studies have shown significant increase of the mean aortic diastolic pressure, the diastolic pressure-time index, endocardial viability ratio, cardiac output, ejection fraction, coronary cerebral and renal blood flow, lactate utilization and myocardial oxygen supply and significant decrease of the systolic aortic pressure, left-ventricular end-diastolic pressure, left-ventricular work, tension time index, myocardial oxygen consumption and lactate production. In similar studies, intraaortic balloon pump (IABP) decreases the size of myocardial infarction. New IABP driving systems, small size sheaths and balloon catheters for percutaneous insertion made the use of the IABP easier and safer. The paraaortic counterpulsation device is suitable for chronic mechanical assistance. It is more effective than the IABP and shows excellent biocompatibility in chronic experiments. Its clinical application in 3 patients showed excellent biocompatibility and promising hemodynamic effects. In conclusion, the salutary hemodynamic effects of the IABP have been shown in several experimental studies. The technical improvements and the development and use of new devices suggest that we still need to learn more about the usefulness of the counterpulsation technique.

摘要

如今,主动脉内球囊反搏术的实施原理与1962年首次用于实验时所描述的相同。实验研究表明,平均主动脉舒张压、舒张压-时间指数、心内膜活力比率、心输出量、射血分数、冠状动脉、脑和肾血流量、乳酸利用率以及心肌氧供均显著增加,而主动脉收缩压、左心室舒张末期压力、左心室做功、张力时间指数、心肌氧耗量和乳酸生成则显著降低。在类似研究中,主动脉内球囊泵(IABP)可减小心肌梗死面积。新型IABP驱动系统、用于经皮插入的小尺寸鞘管和球囊导管使IABP的使用更加简便和安全。主动脉旁反搏装置适用于慢性机械辅助。它比IABP更有效,且在慢性实验中显示出优异的生物相容性。其在3例患者中的临床应用显示出优异的生物相容性和良好的血流动力学效应。总之,多项实验研究已证实IABP具有有益的血流动力学效应。技术改进以及新装置的研发和使用表明,我们仍需进一步了解反搏技术的效用。

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