Kimura S, Morimoto T, Uyama T, Monden Y, Kinouchi Y, Iritani T
Second Department of Surgery, School of Medicine, University of Tokushima, Japan.
Chest. 1994 Jun;105(6):1679-82. doi: 10.1378/chest.105.6.1679.
The electrical impedance of a pulmonary mass was measured in 53 patients of whom 44 had primary lung cancer, 5 had metastatic lung tumor, and 4 had organizing pneumonia. Because biologic tissue can be regarded, electrically, to consist of extracellular resistance (Re), intracellular resistance (Ri), and the electrical capacitance of the cell membrane (Cm), these three parameters were calculated from the measured electrical impedance of tissue by a curve-fitting technique using a computer program. The Re of lung tissue was significantly greater (p < 0.01) and the Cm of lung tissue was significantly less (p < 0.01) than that of a pulmonary mass. The Re of malignant tumors (both lung cancer and metastatic tumors) was significantly greater (p < 0.01) and the Cm of malignant tumors was significantly less (p < 0.01) than that of organizing pneumonia. With this information, we used a biopsy needle to diagnose nine intrathoracic lesions. This technique additionally allowed us to confirm the proximity of the needle tip of the mass. The electrical impedance of the lung mass was measured through the biopsy needle using a modified impedance analysis system before the biopsy was performed. There were no false-negative results, and one false-positive result. The rapid measurement of the electrical impedance of a pulmonary mass, preoperatively, may be of value in the clinical evaluation of a pulmonary mass both by facilitating needle guidance and by permitting diagnosis based on electrical impedance.
对53例患者的肺部肿块进行了电阻抗测量，其中44例患有原发性肺癌，5例患有转移性肺肿瘤，4例患有机化性肺炎。由于生物组织在电学上可被视为由细胞外电阻（Re）、细胞内电阻（Ri）和细胞膜电容（Cm）组成，因此通过使用计算机程序的曲线拟合技术，根据测量的组织电阻抗计算这三个参数。肺组织的Re显著更高（p < 0.01），肺组织的Cm显著更低（p < 0.01），均低于肺部肿块。恶性肿瘤（肺癌和转移性肿瘤）的Re显著更高（p < 0.01），恶性肿瘤的Cm显著更低（p < 0.01），均低于机化性肺炎。利用这些信息，我们使用活检针诊断了9例胸内病变。该技术还使我们能够确定肿块活检针尖端的位置。在进行活检前，使用改良的阻抗分析系统通过活检针测量肺部肿块的电阻抗。没有假阴性结果，有1例假阳性结果。术前快速测量肺部肿块的电阻抗，通过辅助针引导和基于电阻抗进行诊断，可能对肺部肿块的临床评估有价值。
