Kumari D, Sinha S P
Department of Zoology, Bhagalpur University, India.
Food Chem Toxicol. 1994 May;32(5):471-5. doi: 10.1016/0278-6915(94)90044-2.
Ochratoxin (1 microgram/kg body weight/day), when administered orally daily to albino Swiss mice for 14 continuous days, increased the incidence of abnormalities in mitotic and meiotic metaphase chromosomes, and the gross morphology of the sperm head; the sperm count per unit volume of caput epididymal suspension also decreased. These genotoxic effects were substantially reduced by concurrent oral administration of retinol at double the clinically therapeutic dose. It is possible that the electrophilic metabolites of ochratoxin form adducts with DNA or produce replacement-type mutations. Retinol may achieve its antigenotoxic effect by means of blocks and shunts in the ochratoxin metabolic pathway. Vitamin A-mediated cellular repair and scavenging of the mutagenic radicals can also take place. The vitamin itself has some genotoxic potential.
赭曲霉毒素（每天按每千克体重1微克口服给药），连续14天每天对白化瑞士小鼠口服给药后，有丝分裂和减数分裂中期染色体异常的发生率增加，精子头部的大体形态也发生改变；附睾头部悬浮液单位体积的精子计数也降低。同时以临床治疗剂量的两倍口服视黄醇，这些遗传毒性作用会显著降低。赭曲霉毒素的亲电代谢产物有可能与DNA形成加合物或产生替代型突变。视黄醇可能通过阻断和分流赭曲霉毒素代谢途径来发挥其抗遗传毒性作用。维生素A介导的细胞修复和对诱变自由基的清除也可能发生。维生素本身也有一定的遗传毒性潜力。
