Dhar J, Arya O P, Timmins D J, Moss S, Mukembo S, Alawattegama A B, Williams O
University Department of Genito-Urinary Medicine, Royal Liverpool University Hospital, UK.
Genitourin Med. 1994 Apr;70(2):121-3. doi: 10.1136/sti.70.2.121.
To evaluate the efficacy and safety of a 3 day course of 2% clindamycin cream in the treatment of bacterial vaginosis.
A prospective, randomised, double blind, placebo controlled study.
Department of Genitourinary Medicine, Royal Liverpool University Hospital.
55 female patients aged 18 years and over, and premenopausal, who spontaneously or after questioning complained of symptoms of bacterial vaginosis.
55 patients were enrolled. 44 patients were evaluable at Visit 1 when among the 23 who received clindamycin cream bacterial vaginosis was not present in 22 (95.6%) and only one failed treatment. Of the 21 patients in the placebo group only one (4.8%) patient was cured and 20 (95.2%) were failures. Of the 17 patients evaluable at Visit 2 in the clindamycin group, bacterial vaginosis was not present in 14 (82.4%) and had recurred in three. No serious adverse events were noted in either group.
This pilot study provides encouraging evidence of the efficacy and safety of a 3 day course of 2% clindamycin cream in bacterial vaginosis.
评估2%克林霉素乳膏3日疗程治疗细菌性阴道病的疗效和安全性。
一项前瞻性、随机、双盲、安慰剂对照研究。
皇家利物浦大学医院泌尿生殖医学科。
55名年龄在18岁及以上的绝经前女性患者，她们自发或经询问后诉说有细菌性阴道病症状。
共纳入55名患者。44名患者在第1次随访时可进行评估，在接受克林霉素乳膏治疗的23名患者中，22名（95.6%）不存在细菌性阴道病，只有1名治疗失败。在安慰剂组的21名患者中，只有1名（4.8%）患者治愈，20名（95.2%）治疗失败。在克林霉素组第2次随访时可进行评估的17名患者中，14名（82.4%）不存在细菌性阴道病，3名复发。两组均未观察到严重不良事件。
这项初步研究为2%克林霉素乳膏3日疗程治疗细菌性阴道病的疗效和安全性提供了令人鼓舞的证据。
