Urasaki M, Ogura C, Hirano K, Tomori K
Department of Neuropsychiatry, University of the Ryukyus School of Medicine, Okinawa, Japan.
Jpn J Psychiatry Neurol. 1994 Mar;48(1):111-21. doi: 10.1111/j.1440-1819.1994.tb03004.x.
The effects of gamma-aminobutyric acid (GABA) mimetic drug sodium valproate (VPA) on event-related potentials (ERPs) were investigated in 18 healthy volunteers during an auditory odd ball task. VPA (200 or 400 mg) or an inactive placebo was administered according to a completely randomized double-blind, cross-over design. ERPs were recorded one hour after medication was given. VPA did not affect the latencies of N100, P200, N200 and P300. Although on the whole VPA had no effect on the amplitudes of the ERP components in the subjects, it increased the P300 amplitude in the low P300 amplitude subjects and decreased it in the high P300 amplitude subjects. This tendency toward a bidirectional response was also seen in the P200 and N200 amplitudes. It was concluded that the response which takes place being dependent on the difference in the initial values was recognized on the effect of a single administration of 200 or 400 mg VPA to ERPs. The results of this study are discussed, especially in relation to the law of initial value.
在一项听觉Oddball任务中，对18名健康志愿者研究了γ-氨基丁酸（GABA）模拟药物丙戊酸钠（VPA）对事件相关电位（ERP）的影响。按照完全随机双盲交叉设计给予VPA（200或400mg）或无活性安慰剂。给药1小时后记录ERP。VPA不影响N100、P200、N200和P300的潜伏期。虽然总体上VPA对受试者ERP成分的波幅没有影响，但它增加了P300波幅低的受试者的P300波幅，并降低了P300波幅高的受试者的P300波幅。在P200和N200波幅中也观察到这种双向反应趋势。得出的结论是，单次给予200或400mg VPA对ERP的影响呈现出依赖于初始值差异的反应。对本研究结果进行了讨论，特别是与初始值定律相关的内容。
