针对小鼠颗粒子宫腺细胞表面和细胞内抗原的单克隆抗体。

Monoclonal antibodies directed against surface and intracellular antigens of mouse granulated metrial gland cells.

作者信息

Stewart I J, Mukhtar D D, Sawyer A M, Wild A E

机构信息

Faculty of Medicine, School of Biological Sciences, University of Southampton, UK.

出版信息

J Immunol Methods. 1994 Jun 3;172(1):125-30. doi: 10.1016/0022-1759(94)90385-9.

DOI:10.1016/0022-1759(94)90385-9

PMID:8207261

Abstract

Rat monoclonal antibodies with reactivity directed against mouse GMG cells have been produced. One of the antibodies (GMG-1) reacts with a surface antigen of GMG cells and cross-reacts with T lymphocytes. Another (GMG-2) reacts with an intracellular antigen in GMG cells and with asialo-GM1 positive cells in the spleen. Three antibodies (GMG-3, -4, -5) bind to intracellular antigens in GMG cells. The cross-reactivity of these antibodies is discussed with reference to the lineage relationship of GMG cells to NK cells and T cells and the recent suggestion that NK cells and T cells have a common progenitor cell. It is proposed that GMG cells share this common progenitor cell but are otherwise independent of the NK or T cell lineages.

摘要

已制备出对小鼠GMG细胞具有反应性的大鼠单克隆抗体。其中一种抗体（GMG-1）与GMG细胞的表面抗原发生反应，并与T淋巴细胞发生交叉反应。另一种抗体（GMG-2）与GMG细胞中的细胞内抗原以及脾脏中去唾液酸GM1阳性细胞发生反应。三种抗体（GMG-3、-4、-5）与GMG细胞中的细胞内抗原结合。参照GMG细胞与NK细胞和T细胞的谱系关系以及最近关于NK细胞和T细胞具有共同祖细胞的观点，讨论了这些抗体的交叉反应性。有人提出，GMG细胞共享这种共同祖细胞，但在其他方面独立于NK或T细胞谱系。