Wolff D, Goldberg V M, Stevenson S
Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio.
J Orthop Res. 1994 May;12(3):439-46. doi: 10.1002/jor.1100120317.
We used a rat femoral diaphyseal defect/implant model to quantify the ingrowth of bone, cartilage, and fibrous connective tissue in a comparative study of woven sintered titanium fibermetal and porous hydroxyapatite/tricalcium phosphate ceramic implanted with and without the addition of syngeneic bone marrow cells. The patterns of tissue growth into the implants were analyzed with respect to time, type of implant, and the presence or absence of syngeneic marrow. Significantly more bone was found in ceramic implants than in fibermetal implants, with the addition of syngeneic marrow than without it, and at 4 months than at 2 months. Significantly more bone was found at both time periods in ceramic implants with bone marrow than in any other combination studied. We hypothesize that these findings resulted from interactions between the implanted material and its surroundings, specifically its ability to serve as a substratum for cell attachment, and cells in and around the defect, whether surgically implanted or arising from the soft-tissue bed.
我们使用大鼠股骨干缺损/植入物模型，在一项比较研究中，对编织烧结钛纤维金属和多孔羟基磷灰石/磷酸三钙陶瓷在添加和不添加同基因骨髓细胞的情况下植入后骨、软骨和纤维结缔组织的长入情况进行量化。根据时间、植入物类型以及同基因骨髓的有无，分析组织向植入物内生长的模式。与纤维金属植入物相比，陶瓷植入物中发现的骨组织明显更多；添加同基因骨髓的比未添加的更多；4个月时比2个月时更多。在两个时间段内，添加骨髓的陶瓷植入物中发现的骨组织都比所研究的任何其他组合明显更多。我们推测，这些发现是由植入材料与其周围环境之间的相互作用导致的，特别是其作为细胞附着基质的能力，以及缺损内和周围的细胞，无论这些细胞是通过手术植入的还是来自软组织床。
