Koster F T, Palmer D L, Chakraborty J, Jackson T, Curlin G C
Am J Clin Nutr. 1987 Jul;46(1):115-20. doi: 10.1093/ajcn/46.1.115.
A year-long prospective study of 152 Bangladeshi children with mild to moderate protein-calorie malnutrition related nutritional status and cellular immune defects to morbidity due to diarrheal, respiratory, and febrile diseases. In children older than 36 mo, wasting correlated with skin test anergy to three recall antigens and with inability to initiate hypersensitivity to dinitrochlorobenzene. In this older age group, anergy was associated with a 58% increased attack rate and an 83% increased duration of diarrheal diseases but not with febrile or respiratory infections. In stepwise regression analysis, this anergy effect was independent of the small negative impact of poorer nutritional status on morbidity. Ninety-three percent of diarrheal illnesses lasting at least 14 d were among anergic children. Cellular immune incompetence, indicated by anergy of unknown etiology, is associated with increased diarrheal morbidity and may promote the vicious cycle of repeated infections and deteriorating nutritional status.
一项为期一年的前瞻性研究，对象为152名患有轻度至中度蛋白质 - 热量营养不良相关营养状况及细胞免疫缺陷的孟加拉儿童，研究其腹泻、呼吸道和发热性疾病的发病情况。在36个月以上的儿童中，消瘦与对三种回忆抗原的皮肤试验无反应性以及无法对二硝基氯苯引发超敏反应相关。在这个年龄较大的组中，无反应性与腹泻疾病的发病率增加58%以及病程延长83%相关，但与发热或呼吸道感染无关。在逐步回归分析中，这种无反应性效应独立于较差营养状况对发病率的微小负面影响。持续至少14天的腹泻疾病中有93%发生在无反应性儿童中。病因不明的无反应性所表明的细胞免疫功能不全与腹泻发病率增加相关，并可能促进反复感染和营养状况恶化的恶性循环。
