Krishnan U, Willeke K, Juozaitis A, Myojo T, Talaska G, Shukla R
Department of Environmental Health, University of Cincinnati, OH 45267-0056.
Am Ind Hyg Assoc J. 1994 Apr;55(4):309-14. doi: 10.1080/15428119491018943.
Variation in fit factors during quantitative respirator fit testing was studied for a high degree of fit (aerosol fit factors > 1000) and a low degree of fit (aerosol fit factors < 1000). In a controlled human study, fit factors were determined sequentially for three different exercises by (1) an aerosol fit test (using a portable condensation nuclei counter and room aerosol as the test agent) and (2) the newly developed dichotomous-flow fit test (Dichot). For the higher level of respirator fit, the aerosol fit factors were 30 to 60 times the corresponding flow fit factors, and for the lower level of respirator fit they were 2 to 4 times the flow fit factors. A coefficient of variation (CV) of 84% (GSD 1.6) for the higher respirator fit and 178% (GSD 2.2) for the lower respirator fit data was observed in the human study when aerosol fit factors for the three exercises were pooled. In a similar mannequin study, the center sampling probe gave aerosol fit factors with a CV of 5.4% (GSD 1.05). The flow fit factors for all three exercises pooled had a CV of 36% (GSD 1.3) for the higher respirator fit and 40% (GSD 1.5) for the lower respirator fit data, while the mannequin study gave flow fit factors with a CV of 2.2% (GSD 1.02). Thus, the variation in fit factors obtained in the human study was much higher than that obtained in a mannequin study. However, the variation in the aerosol method relative to the flow method, in the human study, os of the same order of magnitude as in the mannequin study.(ABSTRACT TRUNCATED AT 250 WORDS)
针对高度贴合（气溶胶贴合因子>1000）和低度贴合（气溶胶贴合因子<1000）的情况，研究了定量呼吸器贴合测试过程中贴合因子的变化。在一项人体对照研究中，通过（1）气溶胶贴合测试（使用便携式凝结核计数器和室内气溶胶作为测试剂）和（2）新开发的二分流贴合测试（Dichot），依次测定了三种不同运动的贴合因子。对于较高水平的呼吸器贴合，气溶胶贴合因子是相应流量贴合因子的30至60倍，而对于较低水平的呼吸器贴合，它们是流量贴合因子的2至4倍。在人体研究中，当汇总三种运动的气溶胶贴合因子时，观察到较高呼吸器贴合数据的变异系数（CV）为84%（几何标准差GSD为1.6），较低呼吸器贴合数据的变异系数为178%（GSD为2.2）。在一项类似的人体模型研究中，中心采样探头给出的气溶胶贴合因子的CV为5.4%（GSD为1.05）。汇总所有三种运动的流量贴合因子，较高呼吸器贴合数据的CV为36%（GSD为1.3），较低呼吸器贴合数据的CV为40%（GSD为1.5），而人体模型研究给出的流量贴合因子的CV为2.2%（GSD为1.02）。因此，人体研究中获得的贴合因子变化远高于人体模型研究。然而，人体研究中气溶胶方法相对于流量方法的变化与人体模型研究中的变化处于同一数量级。（摘要截取自250字）
