Grandinetti A, Morens D M, Reed D, MacEachern D
University of Hawaii School of Public Health, Honolulu.
Am J Epidemiol. 1994 Jun 15;139(12):1129-38. doi: 10.1093/oxfordjournals.aje.a116960.
A 26-year follow-up study of 8,006 men enrolled in the Honolulu Heart Program examined the effect of cigarette smoking on the risk of developing idiopathic Parkinson's disease. Cases were identified through an ongoing search of hospital records and by the review of death certificates and medical records of local neurologists. Men who had smoked cigarettes at any time prior to study enrollment in 1965 had a reduced risk of developing idiopathic Parkinson's disease (relative risk = 0.39). Examination of smoking by pack-years revealed an apparent dose-response effect on the risk of idiopathic Parkinson's disease, but not on the age of onset. Coffee drinking was also associated with reduced risk, apparently because of its association with cigarette smoking. Although the detrimental health effects of cigarette smoking would far outweight any possible protective effect for smoking and Parkinson's disease, the association of smoking with apparent protection may contribute to understanding the underlying pathogenetic mechanisms.
一项针对参与檀香山心脏项目的8006名男性进行的长达26年的随访研究，考察了吸烟对患特发性帕金森病风险的影响。通过持续检索医院记录以及查阅当地神经科医生的死亡证明和病历，确定了病例。在1965年研究入组前曾在任何时间吸烟的男性，患特发性帕金森病的风险降低（相对风险=0.39）。按吸烟包年数对吸烟情况进行分析发现，吸烟对特发性帕金森病风险存在明显的剂量反应效应，但对发病年龄没有影响。喝咖啡也与风险降低有关，显然是因为它与吸烟有关。尽管吸烟对健康的有害影响远远超过吸烟与帕金森病之间任何可能的保护作用，但吸烟与明显的保护作用之间的关联可能有助于理解潜在的发病机制。
