Mousavi Y, Adlercreutz H
Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland.
Steroids. 1993 Jul;58(7):301-4. doi: 10.1016/0039-128x(93)90088-5.
Studies have indicated a correlation between a high level of urinary lignans and isoflavonoid phytoestrogens, particularly genistein, and a low incidence of hormone-dependent cancers, such as breast and prostate cancer. Previously it has been observed that a vegetarian diet is associated with high plasma levels of sex hormone-binding globulin (SHBG), reducing clearance of sex hormones and probably risk of breast and prostate cancer. In the present study we investigated the in vitro effect of genistein on the production of SHBG by human hepatocarcinoma (Hep-G2) cells in culture and its effect on cell proliferation. We found that genistein not only highly significantly increases the SHBG production by Hep-G2 cells, but also suppresses the proliferation of these cancer cells already at a stage when SHBG production continues to be high. We conclude that, in addition to the lignan enterolactone, the most abundant urinary isoflavonoid genistein stimulates SHBG production and inhibits Hep-G2 cancer cell proliferation.
研究表明，高水平的尿木脂素和异黄酮类植物雌激素，特别是染料木黄酮，与激素依赖性癌症（如乳腺癌和前列腺癌）的低发病率之间存在关联。此前已观察到，素食与血浆中高水平的性激素结合球蛋白（SHBG）有关，这会降低性激素的清除率，并可能降低患乳腺癌和前列腺癌的风险。在本研究中，我们调查了染料木黄酮对培养的人肝癌（Hep-G2）细胞产生SHBG的体外影响及其对细胞增殖的影响。我们发现，染料木黄酮不仅能高度显著地增加Hep-G2细胞产生SHBG，而且在SHBG产量持续较高的阶段就已经抑制了这些癌细胞的增殖。我们得出结论，除了木脂素肠内酯外，尿液中含量最丰富的异黄酮染料木黄酮能刺激SHBG的产生，并抑制Hep-G2癌细胞的增殖。
