Suda M, Sakuhara T, Murakami Y, Karube I
Research Laboratory for Advanced Technology, Seiko Instruments Inc., Chiba, Japan.
Appl Biochem Biotechnol. 1993 Apr-May;41(1-2):11-5. doi: 10.1007/BF02918522.
Micromachining techniques were applied to construct biosensor systems. The micromachined biosensors have small size, low production cost, and good reproducibility. We made some detection units for flow injection analysis (FIA). An electrochemical flow cell was fabricated, and both the enzyme immobilized column and electrochemical detector were integrated onto the same chip. A chemiluminescence detector was also fabricated and applied to the determination of glucose and lactic acid contained in human serum and urine.
微加工技术被应用于构建生物传感器系统。微加工生物传感器具有尺寸小、生产成本低和重现性好的特点。我们制作了一些用于流动注射分析（FIA）的检测单元。制造了一个电化学流通池，并将酶固定柱和电化学检测器集成到同一芯片上。还制造了一个化学发光检测器，并将其应用于测定人血清和尿液中所含的葡萄糖和乳酸。
