Sick building syndrome in a Canadian office complex.

A comprehensive questionnaire survey with limited environmental measurements was undertaken in a large sealed office complex where health complaints had been made by employees since the complex was first occupied. Most respondents suffered from upper respiratory tract irritation, eye and skin irritation, and many less specific complaints. Symptoms started shortly after first employment, were troublesome only at work, and persisted at other work locations within the complex. Employees who worked in cubicles tended to complain more than those who worked in open areas or closed offices; however, evidence of less than optimal ventilation, temperature, and humidity correlated poorly with symptom prevalence. The building was designed and ventilated for open-plan use; later partition into offices and cubicles appeared to aggravate the situation. Although concern about pregnancy outcome was expressed by women who conceived while employed at the complex, rates of spontaneous abortion and fetal defect were close to expectation.