Brauer Charlotte, Kolstad Henrik, Ørbaek Palle, Mikkelsen Sigurd
Department of Occupational Medicine, Copenhagen University Hospital, Glostrup, Denmark.
Int Arch Occup Environ Health. 2006 Jun;79(6):453-64. doi: 10.1007/s00420-005-0074-3. Epub 2006 Jan 11.
To examine associations between perceived indoor environment at work and the non-specific symptoms that are often referred to as the sick building syndrome (SBS), using cross-sectional and prospective analyses for a large cohort from the general population.
The sample comprised 2,164 adults in employment, who completed a postal questionnaire in April 2001. Of these 1,402, who were still working and living in the same place, completed a second questionnaire a year later. The outcome measures were the prevalence of mucous membrane symptoms and general symptoms at baseline and the incidence and persistence of these symptoms at follow-up. Self-reports of the indoor environment from the baseline questionnaire were used as predictors in the analyses.
Inconsistent results were found between the cross-sectional and the longitudinal analyses for the associations between perceived indoor environment factors at work and symptoms. Whereas mucous membrane symptoms in the cross-sectional analysis were significantly associated with self-reported high temperature and dry air, the prospective analyses showed that onset of mucous membrane symptoms was associated with the sensation of draught, dry air, and noise. Persistent mucous membrane symptoms were associated only with stuffy air. General symptoms were associated with self-reported stuffy air and dry air in the cross-sectional analysis, while draught was the only predictor of onset of general symptoms. We found no predictors in the indoor environment for the persistence of general symptoms.
The symptoms that are often connected with SBS are very common symptoms in the general population among manual workers as well as non-manual workers. Our study gives only limited support to the hypothesis of causal relationships between the indoor environment and these symptoms. We found no evidence of persistent mucous membrane symptoms and general symptoms related to specific factors in the indoor environment.
通过对来自普通人群的大型队列进行横断面分析和前瞻性分析，研究工作场所的室内环境认知与通常被称为“病态建筑综合征”（SBS）的非特异性症状之间的关联。
样本包括2164名在职成年人，他们于2001年4月完成了一份邮寄问卷。其中1402人仍在原工作和居住地点，一年后完成了第二份问卷。结果指标为基线时黏膜症状和一般症状的患病率，以及随访时这些症状的发病率和持续情况。基线问卷中关于室内环境的自我报告被用作分析中的预测因素。
在工作场所室内环境因素认知与症状之间的关联方面，横断面分析和纵向分析结果不一致。横断面分析中，黏膜症状与自我报告的高温和干燥空气显著相关，而前瞻性分析表明，黏膜症状的发作与通风感、干燥空气和噪音有关。持续性黏膜症状仅与闷热空气有关。横断面分析中，一般症状与自我报告的闷热空气和干燥空气有关，而通风是一般症状发作的唯一预测因素。我们未发现室内环境中有预测一般症状持续情况的因素。
通常与SBS相关的症状在体力劳动者和非体力劳动者的普通人群中是非常常见的症状。我们的研究仅为室内环境与这些症状之间存在因果关系的假设提供了有限的支持。我们没有发现与室内环境特定因素相关的持续性黏膜症状和一般症状的证据。
