López-Carillo L, López-Cervantes M
Center for Research in Public Health, National Institute of Public Health, Morelos, México.
Arch Environ Health. 1993 Sep-Oct;48(5):359-63. doi: 10.1080/00039896.1993.9936726.
In this paper are reported the effects of organophosphate pesticide exposure. Agricultural workers were compared with an age- and sex-matched control group selected from the general population. A significant difference was detected (Student's t = 1.99, p = .05) between the median activity levels of serum cholinesterase in agricultural workers at the end of the work day (mean 4.44, 95% CI = 4.12-4.77), compared with those in the control group (mean = 4.85, 95% CI = 4.57-5.13). The decrease in cholinesterase activity, measured at the beginning (mean = 4.70, 95% CI = 4.38-5.02) and end of the work day, was very significant (paired t = 2.70, p = .01). An interaction was identified between the type of work and the worker's age. Younger workers tended to perform more dangerous activities, and they experienced a greater decrease in cholinesterase activity. This study indicates that subclinical intoxication of agricultural workers, by pesticides, is occurring in Mexico and indicates the need for primary prevention programs that address occupational contact with such substances.
本文报道了有机磷农药暴露的影响。将农业工人与从普通人群中选取的年龄和性别匹配的对照组进行比较。在工作日结束时，农业工人血清胆碱酯酶的中位活性水平（均值4.44，95%置信区间=4.12 - 4.77）与对照组（均值=4.85，95%置信区间=4.57 - 5.13）之间检测到显著差异（学生t检验=1.99，p = 0.05）。在工作日开始时（均值=4.70，95%置信区间=4.38 - 5.02）和结束时测量的胆碱酯酶活性下降非常显著（配对t检验=2.70，p = 0.01）。工作类型与工人年龄之间存在相互作用。年轻工人往往从事更危险的活动，并且他们的胆碱酯酶活性下降幅度更大。这项研究表明，在墨西哥，农业工人正发生农药亚临床中毒情况，并表明需要开展针对职业接触此类物质的一级预防项目。
