Ulbig M W, Hamilton A M
Moorfields Eye Hospital, Retinal Diagnostic Department, London.
Ophthalmologe. 1993 Oct;90(5):457-62.
The recently introduced semiconductor diode laser is portable, more compact, and cheaper to maintain than other laser systems. It is unclear whether its wavelength characteristics in the near infrared (810 nm) lead to different clinical results of retinal photocoagulation. In a prospective study ten diabetics (3 type I and 7 type II) ranging in age from 26 to 72 years with bilateral proliferative or severe nonproliferative diabetic retinopathy and visual acuity better than 6/18 in both eyes underwent panretinal photocoagulation. One eye was treated with the diode laser, the fellow eye with argon green (514 nm). Follow-up was documented by best-corrected visual acuity, fundus photography and fluorescein angiography. Mean duration of follow-up was 12 months. In neither group was there a significant difference in the response of retinopathy and neovascularization to the treatment, or in the course of visual acuity. Fluorescein angiography revealed the more profound effects of the diode laser in the choroid. Compared to argon laser treatment, patients found diode laser treatment more painful, but appreciated the absence of bright flashes during therapy. Photocoagulation for diabetic retinopathy using the diode laser was as effective as using the argon system in this initial pilot study.
最近推出的半导体二极管激光器便于携带，比其他激光系统更紧凑，维护成本更低。目前尚不清楚其近红外（810nm）的波长特性是否会导致视网膜光凝的临床结果有所不同。在一项前瞻性研究中，10名年龄在26至72岁之间的糖尿病患者（3名I型和7名II型），患有双侧增殖性或重度非增殖性糖尿病视网膜病变，双眼视力均优于6/18，接受了全视网膜光凝治疗。一只眼睛用二极管激光治疗，另一只眼睛用氩绿激光（514nm）治疗。通过最佳矫正视力、眼底摄影和荧光素血管造影记录随访情况。平均随访时间为12个月。两组在视网膜病变和新生血管对治疗的反应或视力变化过程中均无显著差异。荧光素血管造影显示二极管激光对脉络膜的影响更为显著。与氩激光治疗相比，患者发现二极管激光治疗更疼痛，但对治疗过程中没有强光闪烁表示满意。在这项初步的试点研究中，使用二极管激光进行糖尿病视网膜病变的光凝治疗与使用氩激光系统一样有效。
