Górecka D, Górski T
Sanitary Epidemiological Station, Lodz, Poland.
Pol J Occup Med Environ Health. 1993;6(2):143-8.
Genotoxic compounds and various cancer chemotherapeutic agents can interact with tobacco smoke synergistically, especially among cigarette smoking nurses handling cytostatic drugs. The aim of the study was to examine the hypothesis that tobacco smoking has a greater influence on sister chromatid exchange (SCE) frequencies among nurses than the influence of cytostatics in working conditions. The frequencies of SCE in lymphocytes investigated among hospital staff who handle anti-cancer drugs were higher than in a control group which did not handle them (smokers and non-smokers). The increase of SCE frequencies was observed more often among cigarette smoking nurses and less among non-smoking nurses who handle cytostatics 3 times a week.
遗传毒性化合物和各种癌症化疗药物可与烟草烟雾产生协同作用，尤其是在接触细胞毒性药物的吸烟护士中。本研究的目的是检验这样一个假设：在工作环境中，吸烟对护士姐妹染色单体交换（SCE）频率的影响大于细胞毒性药物的影响。在处理抗癌药物的医院工作人员中检测到的淋巴细胞SCE频率高于未处理抗癌药物的对照组（吸烟者和非吸烟者）。每周处理3次细胞毒性药物的吸烟护士中SCE频率增加更为常见，而不吸烟护士中则较少。
